SEMAX

Semax is a synthetic heptapeptide analog of the adrenocorticotropic hormone (ACTH) fragment 4-10, bearing the sequence Met-Glu-His-Phe-Pro-Gly-Pro, with the C-terminal Pro-Gly-Pro extension serving as a metabolic stabilizer. This structural modification confers enhanced resistance to aminopeptidase and carboxypeptidase degradation, extending the effective experimental window of the peptide in cell culture and tissue preparation studies. Semax has been a cornerstone reagent in neuroscience research for investigating neurotrophic and neuroprotective signaling mechanisms across multiple model systems.