IPAMORELIN

Ipamorelin is a synthetic pentapeptide growth hormone secretagogue that selectively activates the growth hormone secretagogue receptor type 1a (GHS-R1a), also known as the ghrelin receptor. Distinguished from earlier secretagogue compounds by its high receptor selectivity and minimal off-target activity, Ipamorelin does not significantly stimulate the release of cortisol, prolactin, or aldosterone at research-relevant concentrations — a property that has made it the preferred GHS-R agonist for controlled in vitro studies of somatotroph function and neuroendocrine signaling mechanisms.

The amino acid sequence of Ipamorelin (Aib-His-D-2-Nal-D-Phe-Lys-NH2) incorporates non-natural amino acids that confer resistance to proteolytic degradation and enhance binding affinity for the GHS-R1a receptor. In cell-based assays, Ipamorelin stimulates intracellular calcium mobilization through Gq-protein coupling, activates the IP3 signaling pathway, and promotes growth hormone release from pituitary somatotroph cell models. Researchers have also used Ipamorelin to study constitutive activity of the GHS-R1a receptor, its interaction with melanocortin receptor systems, and its role in neuroendocrine signaling networks governing energy balance and metabolic homeostasis.

Each vial contains research-grade Ipamorelin, lyophilized for stability and verified for purity by HPLC and identity by ESI-MS. this peptide is exclusively for scientific research purposes. It is not intended for human consumption or any therapeutic use.